My supplement/drug list for ASD

Discuss autism diets and biomedical treatments of autism.

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FatherOf2
Posts: 1494
Joined: Mon Mar 11, 2013 1:37 am

My supplement/drug list for ASD

Postby FatherOf2 » Sat Apr 08, 2017 1:56 pm

This is a summary of supplements and drugs that I researched and/or tried to help with various symptoms of ASD. Those that had profound positive effect on my autistic son are marked in red. I placed drugs at the end of each section. My current list of supplements is at the end of this post, under the green title. I intend to update the full list and add new sections (hopefully this first post will stay editable). I invite other parents to report their experiences to help others to quickly find a treatment for specific symptoms. I will add other parents recommendations to this list.

Abnormal EEG and seizures (regressive autism is often caused by abnormal EEG activity)
    MCT oil (also kills yeast, can cause anger)
    Vit B6 (causes anger due to MAO)
    Mg (Epsom salt baths are best)
    DMG (inhibits conversion of homocysteine to methionine and SAMe, known to cause anger and SIB)
    Taurine (500mg before bed, helps with sleep, treats mania, better not to discontinue abruptly to avoid seizures)
    Carnosine (causes anger probably because it inhibits DAO, which breaks down histamine)
    Vit E (α-tocopherol)
    Selenium
    Bacopa (slightly better behaviors)
    Vinpocetine
    Bupleurum Chinense
    Frankincense oil
    Vit D
    Trileptal (reduces SIB, side effect: reduces calcium, that is why I use a small dose of 150mg 2x/day)
    Lamictal (Na-channel blocker, also facilitates GABA release and reduces presynaptic release of glutamate, increases socialization and speech, but can cause Stevens-Johnson syndrome)
    Valproic Acid (negatively affects cognition)
    Keppra (beware of 'Keppra rage')
    Gabapentin (claimed by some MAPS doctors to help with speech and reduce stims)
    Prednisone (corticosteroid, those who tried it report amazing results including speech for the first time, but cannot be taken long term)
Avoid: Coffeine (coffee, black or green tea), Aspartame, Tyrosine, Ginkgo Biloba, Ginseng, Sage, Goldenseal/berberine, Evening Primrose, Starflower/borage, St. John's Wort, Uva Ursi, Kava Kava, Yohimbe, Colloidal silver, Copper, ADHD drugs
Caution: Melatonin may increase or decrease seizure activity
Caution: There is a conflicting info on Creatine and seizures. Medical journals write that it actually reduces seizures whereas rare single cases report seizures from it. It is not clear whether seizures while taking Creatine were due to Creatine (high dose?) or exhaustion from exercise (Creatine is a popular supplement among bodybuilders).
Caution: Grapefruit juice and niacin may interact with Tegretol (carbamazepine)

Psychosis and mania (schizophrenia is sometimes diagnosed as ASD in young patients):
    Fish oil (anti-inflammatory, balances dopamine at D1 and D2 receptors)
    Glycine & D Serine (full agonists of NMDA receptors, which are low functioning in schizophrenic patients; Glycine and D Serine give comprehensive improvement in SZ symptoms; Glycine is also inhibitory and should be given at night, D Serine may cause seziures while Glycine may reduces them)
    Sarcosine (can be even more effective than Glycine or D Serine thanks to blocking reuptake of glycine through GlyT1; showed week anti-convulsant properties; DMG is metabolized into Sarcosine)
    NAC (reduces glutamate, often combined with Sarcosine for greater effect))
    B3 + vit C (B3 raises blood sugar)
    Lithium (ionic, lithium orotate never worked for my son)
    BCAA (treats mania)
    Choline (phosphatidyl choline, reduces mania)
    Bupleurum Chinense (D2 blocker)
    Reserpine (blocks VMAT2 and less VMAT1)
    Sodium benzoate (food preservative, inhibits DAO, binds and excretes amino acids reducing ammonia levels, may form carcinogen benzene)
    Risperidone (blocks receptors responsible for schizophrenia symptoms such as D2, inhibits DAO, can cause seizures)
    Abilify (less side effects than Risperidone)
    Clozapine (partial antagonist at 5-HT2A, GABAB agonist, induces release of glutamate and D-serine, can cause seizures)
Avoid: Sugar, Tyrosine, Phenylalanine, B6 (converts L-Dopa to dopamine), Zinc (DA re-uptake inhibitor), Evening Primrose, Chinese Skullcap (DA re-uptake inhibitor), ADHD drugs like Ritalin and Focalin, SAM-e (can induce mania in bipolar patients), D-Cycloserine (partial agonist of NMDA receptors, which acts as antagonist when combined with high levels of agonist, worsening the psychosis).
For MAO mutation avoid: Tyrosine, Tryptophan, Phenylalanine, Spirulina, B6, Zinc

Anger, aggression & self-injurious behavior:
    Eating small meals throughout a day at the same times (to avoid low blood sugar levels)
    EPA-rich fish oil (2-3g, helps to control anger and aggression possibly due to its dopamine and glucose regulation properties)
    Flaxseed oil (anti-androgen)
    Manganese (regulates blood sugar, many hypoglycemia patients swear by it)
    Mg (calming, Epsom salt baths are best, MagMind is also good but I never saw visible effects)
    Lithium (ionic, lithium orotate never worked for my son)
    Reishi (anti-androgen, immune balancing, calming)
    Nicotine patches (calming, reduce SIB, some evidence to help Alzheimer's patients)
    Tennex (reduces impulsivity but can cause drowsiness)
    Verapamil (hypertension drug, Calcium channel blocker, stops anger rages and SIB, off-label used for bipolar disorder)
    Propanolol (another hypertension drug, beta blocker, used to treat anxiety and anger off-label, it improved verbal skills in ASD studies)
    SSRI's (used commonly for depression but also at low doses for anger management off-label)
    Riluzole (blocks glutamate transmission and reuptake of GABA, significantly reduced irritability in trials, increases appetite and weight)
    Spironolactone (aldosterone antagonist and potassium-sparing diuretic, reduces inflammation, lowers testosterone and aggression)
    Low Dose Naltrexone (reduces hyperactivity and SIB, can be taken orally or as cream, affects sleep for the first 2 weeks)
    Trileptal (reduces SIB, also AED, side effect: reduces calcium, that is why I use a small dose of 150mg 2x/day)
    Abilify (less side effects than Risperdal)
    Immune Boosters (GcMAF and Actos are reported by some to reduce meltdowns)
Avoid: anything that increases dopamine such as Sugar, dopamine precursor Tyrosine, another dopamine precursor Phenylalanine, chocolate (contains sugar, Tyrosine and Phenylalanine), B6 (converts L-Dopa to dopamine), Zinc (DA re-uptake inhibitor), Evening Primrose, Chinese Skullcap (DA re-uptake inhibitor), ADHD drugs like Ritalin and Focalin (contain meth, which is DA re-uptake inhibitor).
Avoid: MAO inhibitors such as B6, Zinc, many herbs such as Curcumin
Avoid: Anything that reduces blood sugar: alpha-lipoic acid/ALA, Cinnamon, Curcumin, Ginger, Berberine/Goldenseal, Elderberry, Chamomile, Chinese Skullcap even though it is sometimes used for anger-management, Fenugreek, Stinging Nettle, Gymnema, Aloe, Resveratrol (grape seed extract), most adaptogenic herbs such as Ashwagandha and Ginseng, Chromium, Vanadium, SAMe. Chelation leads to adrenal fatigue, low cortisol and blood sugar levels. It caused extreme defiance in my son that lasted 1.5-2 months after each of the last 3 rounds. Adrenal support supplements didn't help.

Poor focus, memory & cognition:
    Krill oil (contains EPA and DHA bonded with phospholipids - mostly phosphatidylcholine, so you get both Omega 3 and PC)
    Choline (Citicoline or Alpha GPC, increases acetylcholine in the brain, boosts ATP by 14%, much milder effect than Galantamine)
    Phosphatidylserine (no visible effect on cognition, supposed to stabilize cortisol and mood, but we haven't noticed that, causes stims)
    Idebenone (synthetic CoQ10, increases NGF and connectivity between left and right cerebral hemispheres, stimulates synthesis of ATP, currently awaiting FDA approval for treatment of Duchenne Muscular Dystrophy, start with 30mg)
    D Serine (co-agonist of NMDA receptors, enhances cognition in schizophrenia patients, important if DAOA is mutated)
    Carnosine (slightly better cognition, but causes anger probably because it inhibits DAO, which breaks down histamine)
    Creatine (strong effect on cognition & speech, but can cause irritability and SIB possibly due to hypoglycemia, better form is Kre-Alkalyn)
    NADH (active form of B3, with vit C recycles glutathione, increases BH4 & ATP in brain, good supplement for MTHFR A1298C mutation)
    Biotin (in high does of 300mg enhances myelin production and reduces axonal hypoxia through enhanced energy production, used by Multiple Sclerosis patients)
    L-Theanine (can cause mood swings, often combined with Caffeine)
    Iron (iron deficiency can cause ADHD)
    Pycnogenol (no visible effect)
    Bacopa (also anti-seizure, slightly better behaviors, often combined with Panax Ginseng and Rhodiola Rosea)
    Vinpocetine (promotes blood circulation, anti-seizure, no visible effect)
    Gingko Biloba (promotes blood circulation, but may cause seizures)
    Chinese Skullcap (liver toxicity? can cause behaviors as DA re-uptake inhibitor)
    Lion's Mane mushrooms (anti-oxidant, regenerates nerves)
    HBOT (can cause seizures if EEG is abnormal - start AED first, can also cause yeast overgrowth - take Ampho B)
    Leucovorin Calcium (folinic acid, increases hyperactivity, causes anger)
    Piracetam (cyclic derivative of GABA, helped with speech, studied in autistic children, not approved in USA)
    Galantamine (acetylcholinesterase inhibitor, start with 1mg am, effect lasts 2-4 weeks, then either increase dose or cycle On/OFF, may increase seizures in rare cases)
    Huperzine A (another acetylcholinesterase inhibitor, also blocks NMDA, which helps to prevent NMDA-induced seizures)
    Namenda (NMDA receptor blocker, a 'better magnesium', helped with socialization, but led to higher irritability)
    Vayarin (Phosphatidylserine conjugated with Omega 3 EPA and some DHA, it didn't help my son, but some parents report improvements)
    ADHD stimulant drugs Ritalin, Focalin, Adderall, Vyvanse (based on meth and can cause addiction, Schedule II, may cause tics, reduce appetite, carry FDA warning of possibly triggering schizophrenia in predisposed patients due to their dopamine reuptake inhibition)
    Modafinil/Provigil (weak dopamine reuptake inhibitor, studied on children, classified as a schedule IV drug due to its lower addiction potential than other ADHD drugs, may lead to psychosis due to being a partial agonist of D2 receptors, but overall is much safer than other ADHD drugs)

Brain inflammation and oxidative stress (cause glutamate toxicity, seizures, etc):
    Fish Oil (there are some claims that Krill oil is better for inflammation due to higher bioavailibity of EPA and DHA, which are bonded with phospholipids - mostly phosphatidylcholine, so you get both Omega 3 and PC)
    Evening primrose oil (source of GLA)
    Vitamin E + selenium (vit E as Jarrow's Toco-Sorb)
    Vitamin D (anti-inflammatory)
    Vitamin C
    CoEnzyme Q10 (combine with B2)
    Melatonin (1-3mg before bed, helps to fall asleep, not as effective as Taurine in keeping asleep through the whole night)
    NAC (precursor of glutathione, reduces glutamate, but not recommended for long term, can cause yeast overgrowth)
    Alpha-Lipoic Acid or ALA (anti-oxidant, used for chelation, must be careful with dosing, can cause irritability, yeast overgrowth)
    Resveratrol (anti-oxidant, tips glutamate/GABA balance towards GABA, anticonvulsant add-on)
    Cocoa flavanols (anti-oxidant, enhances cortical blood flow, contains DA precursors Tyrosine and Phenylalanine, which can lead to anger)
    Quercetin or Luteolin (antioxidants, block release of glutamate, but can cause irritability due to MAO inhibition, Quercetin had more pronounced effect than Luteolin and didn't cause irritability)
    Sulforaphane (broccoli sprouts extract, no visible effect on my son, seizures is a possible side effect)
    Pycnogenol (anti-oxidant, improves cognition, but we saw no effect)
    Cat's Claw
    Green tea and EGCG
    Turmeric/Curcumin (contains sulfur, inhibits MAO, can increase irritability like in my son)
    Boswellia (as Frankincense oil)
    Lion's Mane mushrooms (anti-oxidant, regenerates nerves, improves cognition)
    Ibuprofen (COX-2 NSAID, typically cycled 1 month on, 1 month off, need support for gut health)
    Celecoxib (another COX-2 NSAID, in studies reduced irritability, long-term use causes GI problems)
    Singulair (lieukotriene inhibitor, zero effect on my son)
    Ketotifen (old allergy drug, noncompetitive H1-antihistamine and mast cell stabilizer, some claim to be very effective)
    Glutathione (delivery is a problem, doesn't absorb orally, creams seem ineffective, never tried nasal sprays, IV push works)
    Spironolactone (aldosterone antagonist and potassium-sparing diuretic, reduces inflammation, lowers testosterone and aggression)
    Prednisone (corticosteroid, those who tried it report amazing results including speech for the first time, but cannot be taken long term, suppresses immune system)
    DMSA & DMPS (chelators but also anti-oxidants, can cause irritability, yeast overgrowth)
Avoid: Stress (inflammation is an early stage of the stress response), poor sleep (increases IL-6), dehydration, sugar and fructose (raise inflammation markers IL-6 and CRP, affect calcium metabolism, and deplete B vitamins), pasteurized, homogenized and otherwise cooked diary products (omega-3 fatty acids are destroyed), trans fats (french fries, potato chips, trans fats inhibit omega-3 metabolism), foods high in omega-6 such as corn (corn syrup is added to almost everything, high fructose corn syrup is the worst, need to balance with omega-3), foods high in MSG, red meat (high in iron, also contains Neu5Gc, which triggers inflammation response), oxidizing minerals (three 'amigos' aluminum, manganese and iron, also high-dose chromium, high-dose selenium), sodium/potassium ratio above 5 or less than 2, calcium/magnesium ratio greater than 10 (especially if combined with a high sodium/potassium ratio), seafood rich in mercury (tuna, shellfish, swordfish, but sardines are OK). untreated PANDAS or Lyme disease, GI infections (candida albicans, clostridia), chlorine and fluoride in tap water, smoking, alcohol, non-steroidal anti-inflammatory drugs such as Tylenol or Aleve, coffee, stimulant ADHD drugs, allergens (casein, gluten, pollen, dust, mold).

Allergies (this could be a single reason for autism in some cases, mast cell activation causes brain fog):
    GFCF diet (if allergies to casein and gluten)
    Cromolyn (stabilizes mast cells, used mostly for acute treatment)
    Quercetin (stabilizes mast cells & reduces CRH hormone that stresses adrenal glands; often taken with Bromelain, which improves absorption; Quercetin is more potent than Cromolyn)
    Forskolin (mast cell stabilizer)
    EGCG (from green tea, inhibits histidine conversion to histamine and stabilizes mast cells, like Quercetin it inhibits IL-6)
    Reishi mushrooms (stabilize mast cells, shift immune balance away from fighting allergies)
    Astragalus (stabilizes mast cells, nourishes the adrenal glands, which is important because histamine burns out the adrenal glands that work to keep inflammation in check)
    Gamma-Linolenic Acid (many take fish oil/omega 3 without supplementing omega 6, but both should be taken together; LA and AA tend to promote inflammation, but GLA may actually reduce inflammation; preferred source of GLA is EPO)
    Copper (required to form DAO enzyme, which breaks down histamine; Cu is also used by MAO anzyme that breaks down dopamine and serotonin; large intake of zinc reduces copper)
    Benadryl (activates DAO, take before bed)
    Minocycline (antibiotic, but often used to reduce microglial activation that plays a role in chronic neurological inflammation; reduces overall levels of IgE)

Anxiety, OCD, poor eye contact, stims, other sensory and social issues
    GFCF diet (even though my son is allergic to milk according to blood test, GFCF didn't help, neither did antihistamines)
    B-Complex (especially B3 and B12, B3 helps to reduce anxiety, but in high doses stresses liver, combine with equal or higher dose of vit C)
    Inositol (IP6 Gold)
    NAC (precursor of glutathione, provides cysteine to bind glutamate, reduces OCD and stims)
    Magnesium + Calcium (I got rid of my panic attacks by drinking milk before bed)
    L-Theanine (can cause mood swings)
    Tryptophan (increases serotonin, reduces anxiety, helps with sleep)
    Quercetin (reduces excess stress hormone corticosterone thus causing an anti-anxiety effect comparable to prescribed drugs)
    Rhodiola Rosea (second most popular adaptogen after panax ginseng, reduces fatigue, increases serotonin and improves mood, reduces corticosteroids and anger, increases focus, can inhibit MAO-A but perhaps not when taken orally, better if cycled 4 weeks on/2 weeks off)
    Honokiol (a phytochemical from Magnolia bark, reduces anxiety by modulating GABA_A receptors, has a comparatively lower risk of causing benzodiazepine-like side effects, such as central depression, muscle relaxation, amnesia, or physical dependence)
    Oxytocin nasal spray (increases socialization)
    R-Baclofen (GABA_B agonist, improves communication and socialization, stabilizes EEG, suppresses PERK/eIF2α signaling responsible for dementia)
    Riluzole (blocks glutamate transmission and reuptake of GABA, reduces OCD, anxiety and irritability, increases appetite and weight)
    Namenda/Memantine (blocks NMDA receptors, reduces OCD and stimming)
    Propranolol (hypertension drug, beta blocker, used to treat anxiety and anger off-label, it improved verbal skills in ASD studies)
    Clonazepam (only tiny non-sedating doses, to treat seizures and panic disorder)
    Celexa and other SSRI's (SSRI's are the key ASD treatment of Dr. Goldberg)
    Chelation (claimed to eliminate many ASD symptoms including stims)

Yeast overgrowth (giggling, goofiness, spinning, stims, fluffy sponge-like poop)
    Probiotics
    Candidase or Candex enzymes (Cellulase and Protease, can cause stomach pain, takes about 4-6 weeks to see results, I never saw anything)
    Biotin (never saw any effect)
    MCT Oil/Caprylic Acid
    Grapefruit Seed Extract/GSE or GFSE (Nutribiotic drops,contains phenols, slows down liver metabolism, use only for 1 week)
    Berberine/Goldenseal (sensitizes neurons to glutamate, inhibits MAO-A, don't use longer than 2 weeks, my son is more aware on it, but eventually develops irritability)
    Garlic (sometimes is added to antifungal enzymes)
    Uva Ursi (can cause seizures and serious liver damage)
    Nystatin (broad spectrum but weak, safe)
    Amphotericin B (my favorite, broad spectrum, very effective and safe if used orally, sold only through compounding pharmacies)
    Diflucan/Fluconazole (because this drug doesn't kill all yeasts and is toxic to liver, only use it if you detected a yeast that this drug kills)
    Ketoconazole (very effective against many yeasts, a 'big gun', toxic to liver)
Avoid: Sugar and and high sugar fruits and juices, carbohydrates, sulfur-based supplements like ALA, NAC, Curcumin, chelating drugs

Bacterial infections (cause poor eye contact, tantrums, aggression, SIB)
    Garlic
    Echinacea (often combined with Goldenseal)
    Berberine/Goldenseal (sensitizes neurons to glutamate, may reduce seizure threshold, inhibits MAO-A, don't use longer than 2 weeks, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107129, my son is more aware on it, but eventually develops irritability)
    Turmeric/Curcumin
    Oil of Oregano
    Flagyl/Metronidazole (most popular add-on of anti-fungal protocols)
    Vancomycin (popular add-on of anti-fungal protocols)
    Alinia (antibiotic and anti-parasite)
Avoid: Colloidal silver. Silver doesn't belong in the body and cannot be excreted, leading to its accumulation and argyria disease.

Viral infection (poor eye contact, tantrums, aggression)
    L-Lysine
    Lauricidin (tastes like soap)
    Elderberry
    Echinacea
    Astragalus
    Cat's Claw
    Olive leaf extract
    Licorice root
    Virastop enzyme
    Valtrex (effective for Herpes family but not RNA viruses like measles and rubella)
    Amantadine (also NMDA antagonist, reduces irritability, hyperactivity and OCD, helps with ADHD)
    Immunovir (immunostimulant, used to treat measles, herpes, wards)
Avoid: Arginine - feeds herpes virus

Immune system dysregulation
    Fish oil (most likely suppresses immune system due to evidence of fish oil increasing prostate cancer risks)
    Evening Primrose Oil (possibly suppresses immune system)
    Castor oil (boosts immune system)
    Vitamin C (if taken before cancer, prevents it; if taken during cancer, promotes it)
    Vitamin D3 (activates immune system)
    B12 (boosts immune system)
    Probiotics (cancer fighting Lactobacillus acidophilus, L bulgaricus, and L casei)
    Zinc (activates immune system)
    Colostrum
    'Hamlet' breast milk compound (just recently discovered in Sweden as a very effective anti-cancer compound)
    DIM/Diindolylmethane (a substance found in cruciferous vegetables, reduces estrogen, anti-cancer)
    Indole-3-carbinol (a substance found in cruciferous vegetables, anti-cancer, fight viruses, detox body)
    Salvestrol (produced by plants in response to fungal infection, used in humans to fight cancers)
    MGN-3/Biobran (complex sugar derived from rice bran treated with extracts from three mushrooms: Shiitake, Coriolus versicolor, and Suehirotake, stimulates immune system)
    IVIG (very powerful but controversial, can bring allergies that didn't exist before depending on the blood donor)
    GcMAF (modified vit D-binding protein, has been promoted as a cure for cancer, HIV, autism, and other conditions, not approved in USA)
    Low-Dose Naltrexone (transdermal once daily between 9pm and 12 am, can disrupt sleep for the first 2 weeks)
    Actos (shifts immune balance from predominant T2 humoral immunity to T1 cellular immunity, improves cognition, calmness, verbal ability, and socialization, reduces aggression)

Toxins, heavy metals
    Chlorella
    Modified citrus pectin
    Vit C (some say it chelates lead at large doses)
    Selenium (co-factor of glutathion production, often combined with vit E and C, Se also has strong binding affinity to mercury, Hg – Se is not absorbed and gets flushed out)
    Sauna (sweating removes toxins)
    Bentonite Clay baths (beware that Bentonite clay contains lead and carries Prop 65 warning in California)
    Glutathione (not absorbed orally, use sublingual, nasal, transdermal or IV push)
    NAC (precursor to glutathione - key detoxifier, combine with Glycine and Mg for more GSH)
    Alpha Lipoic Acid/ALA (antioxidant, neutralizes several toxins including heavy metals, acts as a co-enzyme for recycling glutathione, key supplement in Andy Cutler mercury chelation protocol)
    Milk Thistle (contains Silymarin, protects liver by boosting glutathione)
    Melatonin (hormone known to regulate sleep, also a powerful antioxidant raising glutathione levels)
    Chelation with DMSA, DMPSA, EDTA (can cause irritability)
Avoid: Fish with low selenium relative to mercury such as pilot whale, shark, tilefish, shellfish (particularly mussels and scallops), king mackerel, marlin and swordfish.
Avoid: Eating liver and kidney of animals, rice (there was a study showing that those on GF diet tend to consume more rice products, which are rich in lead and arsenic, causing more harm than gluten), oily seeds, cocoa powder (high lead), raw tea (high lead, ready to drink teas have less lead), dried seaweed (one of the most contaminated foods), dried leaf vegetables or dried mushrooms or dried edible plants or dried herbs (high lead).
Caution: Dietary supplements including herbal extracts have the highest amount of lead, cadmium and arsenic measured in mg/kg (or ppm) among all foods. My advise is to be very selective. See "Food Safety – Heavy Metals in Foodstuffs" reports from USDA.

Non-verbal, delays in expressive and receptive language
    iPad (flashcards and other speech programs)
    Listening therapies (Tomatis, ILS, etc)
    GFCF diet and removal of allergens (even though my son is allergic to milk according to blood test, GFCF didn't help, neither did antihistamines)
    Krill Oil (contains EPA and DHA bonded with phospholipids - mostly phosphatidylcholine, so you get both Omega 3 and PC)
    SPEAK = 725mg EPA + 275mg DHA + 200mg gamma tocopherol + 500IU d-alpha tocopherol + 60mg GLA + 800IU D3 + 1mg K1 + 150mcg K2
    MB12 shots (we had no luck with MB12 or Hydroxy B12 but most other parents report good results)
    B6 + Mg (the most commonly given combo to ASD kids around the globe, B6 can cause higher irritability in presence of MAO mutation)
    DMG (was the very first supplement we tried, it helped my son to start communicating with us through touch, but also caused head banging, which stayed for years even after discontinuation of DMG)
    TMG (TMG activates BHMT pathway of converting homocysteine into methionine and SAMe whereas DMG inhibits BHMT, hard to say if it did anything)
    Acetyl-L-Carnitine (didn't do anything for my son but supposed to help with receptive language)
    Carnosine (zero effect on my son except higher irritability due to DAO inhibition and higher histamine)
    Quercetin (my son is doing great on it, more present, more social, speaks more, happier)
    Creatine (adding it on my own due to impressive results https://www.ncbi.nlm.nih.gov/pubmed/20159424, better form is Kre-Alkalyn)
    Cytoflora
    Antifungal therapy (antifungal + antibiotic, commony used by MAPS doctors, but, in my opinion, it is ineffective)
    HBOT (moved my son to functionally new levels in his development)
    Piracetam (cyclic derivative of GABA, helped with speech, studied in autistic children, not approved in USA)
    Prednisone
    Anti-seizure meds (Lamictal, Trileptal, Keppra, Valproic Acid)
    BH4 (for those with MTHFR A1298C mutation which affects production of dopamine and serotonin; I never tried; sold as very expensive drug Kuvan)
    Chelation (controversial)


CURRENT LIST OF SUPPLEMENTS (6/16/2017):
AM:
    Antarctic Krill Oil with Astaxanthin (1000mg, contains EPA and DHA bonded with PC, helps with speech & focus)
    Vayarin (also helps with focus)
    Doctors Best Fully Active B complex (no visible effect)
    Jarrow Toco-Sorb (mixed Tocotrienols and vit E, supposed to reduce seizures, no visible effect)
    Selenium (200mcg, works with vit E, removes mercury, no visible effect)
    MRM Quercetin QU995 (500mg, reduces histamine, helps with awareness)
    Kre-Alkalyn Creatine (750mg, helps with awareness and muscles)
    Natural Factors Vitamin C Tangy Orange (500mg, chewable, the only vit C that my son likes, no visible effect)
    Potassium (100mg, needed to supplement with Bumetanide, see below)
    Fiber Choice Inulin (2 gummies, according to Nemecheck protocol, I think it makes my son calmer)
    Rx meds: Trileptal (150mg, stabilizes EEG, reduces SIB), Lamictal (50mg, stabilizes EEG, helps with social), Bumetanide (0.5mg, helps with social)
PM:
    Taurine (500mg, helps with sleep, stabilzes EEG)
    Flaxseed Oil (supplies alpha linolenic acid that suppresses immune PERK/eIF2a signaling, which blocks protein synthesis in the brain)
    Fiber Choice Inulin (2 gummies, according to Nemecheck protocol, I think it makes my son calmer)
    Rx meds: Trileptal (150mg, stabilizes EEG, reduces SIB), Lamictal (50mg, stabilizes EEG, helps with social), Bumetanide (0.5mg, helps with social), Lexapro (2.5mg, for anxiety)
Last edited by FatherOf2 on Sat Jun 17, 2017 12:38 am, edited 167 times in total.

antoine
Posts: 16
Joined: Tue Mar 15, 2016 8:47 pm

Re: My supplement/drug list for ASD

Postby antoine » Sun Apr 09, 2017 7:20 pm

Amazing post, thank you!

Nikkie111
Posts: 190
Joined: Thu Sep 24, 2015 6:26 am

Re: My supplement/drug list for ASD

Postby Nikkie111 » Mon Apr 10, 2017 5:41 pm

Fo2 fab list... I think it's be good to have something around Antivirals especially Valtrex which was life saviour for us still can't do without!
And a list for immune regulation like GcMaf and Biobran!

Both these target the cause rather than the symptoms

TravonMom
Posts: 4
Joined: Sat Apr 01, 2017 9:03 pm

Re: My supplement/drug list for ASD

Postby TravonMom » Tue Apr 11, 2017 10:00 am

Awesome Post, Thank You. May I ask what brand of Taurine do you use?

FatherOf2
Posts: 1494
Joined: Mon Mar 11, 2013 1:37 am

Re: My supplement/drug list for ASD

Postby FatherOf2 » Tue Apr 11, 2017 10:03 am

TravonMom wrote:Awesome Post, Thank You. May I ask what brand of Taurine do you use?

It changes all the time depending on which store I go to. Currently the Now brand powder.

TravonMom
Posts: 4
Joined: Sat Apr 01, 2017 9:03 pm

Re: My supplement/drug list for ASD

Postby TravonMom » Tue Apr 11, 2017 10:12 am

Thanks....One more thing can you share the link where you ordered the Piracetam? I thought I wrote it down but I can't find it now

FatherOf2
Posts: 1494
Joined: Mon Mar 11, 2013 1:37 am

Re: My supplement/drug list for ASD

Postby FatherOf2 » Tue Apr 11, 2017 10:31 am

TravonMom wrote:Thanks....One more thing can you share the link where you ordered the Piracetam? I thought I wrote it down but I can't find it now

https://supplements.relentlessimprovement.com/piracetam-p240.aspx?widget=mp

If you are outside US, try to get the branded Nootropil manufactured in UK

ellenjofishel
Posts: 12
Joined: Thu Mar 14, 2013 10:37 am

Re: My supplement/drug list for ASD

Postby ellenjofishel » Tue Apr 11, 2017 3:27 pm

I came on here to get some feedback on Verapamil, did it work at all for you? My son currently takes Lamictal and Buspar to try to control aggressive outbursts/SIBs, and they are working somewhat, but we still have some issues.

Hopefully we will get to try Verapamil after his next appointment. Have been reading about it a lot about it at: http://epiphanyasd.blogspot.com/feeds/posts/default

FatherOf2
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Re: My supplement/drug list for ASD

Postby FatherOf2 » Tue Apr 11, 2017 3:45 pm

ellenjofishel wrote:I came on here to get some feedback on Verapamil, did it work at all for you? My son currently takes Lamictal and Buspar to try to control aggressive outbursts/SIBs, and they are working somewhat, but we still have some issues.

Hopefully we will get to try Verapamil after his next appointment. Have been reading about it a lot about it at: http://epiphanyasd.blogspot.com/feeds/posts/default

That is where I heard of Verapamil first. I haven't tried it on my son yet because his aggression is under control, mostly thanks to Trileptal. Spironalactone is also reported to reduce testosterone and aggression. I am keeping it on my list for the time when my son starts going through puberty.

raun cesar
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Re: My supplement/drug list for ASD

Postby raun cesar » Thu Apr 13, 2017 4:14 am

This list is helpful and amazing....

mommy4ev
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Re: My supplement/drug list for ASD

Postby mommy4ev » Thu Apr 13, 2017 9:43 pm

Thank you! What a WEALTH of knowledge!!!!

Applesaucer
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Re: My supplement/drug list for ASD

Postby Applesaucer » Thu Apr 13, 2017 10:12 pm

FatherOf2, thank you very much for this list -very insightful.
I've been giving high does of Zn and B6 to 6y old ds with MAO A ++ (high dopamine test results) and seeing some really high upticks in irritability, tantrums and anger. Your post was timely.

Look forward to more updates on this thread.

i-jerry
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Re: My supplement/drug list for ASD

Postby i-jerry » Tue Apr 18, 2017 7:20 am

FatherOf2 wrote:
ellenjofishel wrote:I came on here to get some feedback on Verapamil, did it work at all for you? My son currently takes Lamictal and Buspar to try to control aggressive outbursts/SIBs, and they are working somewhat, but we still have some issues.

Hopefully we will get to try Verapamil after his next appointment. Have been reading about it a lot about it at: http://epiphanyasd.blogspot.com/feeds/posts/default

That is where I heard of Verapamil first. I haven't tried it on my son yet because his aggression is under control, mostly thanks to Trileptal. Spironalactone is also reported to reduce testosterone and aggression. I am keeping it on my list for the time when my son starts going through puberty.


Hi fo2, many thanks for the super useful post. We are starting HBOT 1.3 ata 4 weeks ago, 1 hr per day and 5 days a week. in the 20 hrs hbot i didn't see any positive from my son(5.5 yr), but hyper, glue ear(both of us) and yeast problem. I see your son has big progress by using hbot and may i ask which protocol did you use and how long have you notice the progress? Thanks in advance

FatherOf2
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Re: My supplement/drug list for ASD

Postby FatherOf2 » Tue Apr 18, 2017 9:32 am

i-jerry wrote:Hi fo2, many thanks for the super useful post. We are starting HBOT 1.3 ata 4 weeks ago, 1 hr per day and 5 days a week. in the 20 hrs hbot i didn't see any positive from my son(5.5 yr), but hyper, glue ear(both of us) and yeast problem. I see your son has big progress by using hbot and may i ask which protocol did you use and how long have you notice the progress? Thanks in advance

We used 1.5 ata 100% oxygen inside the whole chamber (no oxygen mask needed, the whole body breathes oxygen). The chamber was made by Sechrist. We supplemented with Amphotericin B starting the second week. We saw intermittent gains during the first 15 dives, then behaviors got worse (dives 15-25) due to yeast, then steady gains on dives 25-40. Another waves of gains came 2 months after stopping HBOT. Some people don't see gains during HBOT but see them 2-3 weeks after stopping HBOT. It has something to do with the body reacting to stopping the oxygen as an injury and mobilizing stem cells to repair. These stem cells start growing blood vessels to continue the elevated oxygen supply to all parts of the body (muscles, brain, etc). That is why HBOT is used by athletes to repair their muscle injuries, or diabetes patients to grow blood vessels into affected areas such as legs (FDA approved HBOT for this purpose). Some people don't see any changes depending on the ASD cause. In my son's case, HBOT helped probably because my son's autism is caused by a lack of oxygen supply into brain (he had low RBC, he had a bruise on his head from the c-section delivery, he fell at age 1.5 with blood coming out his ears). I have read other parents who claim that their child's autism was caused by head bruising during delivery (there is a medical term for it - Cephalohaematoma). There is another boy in my son's school, who is also autistic and has exactly the same traits as my son (hand flapping, sensitivity to noise - closing his ears, anxiety, limited interests and OCD - likes to read labels, pale and thin, etc). His autism was caused by complications at birth, which required to surgically remove one of his lungs, which caused poor blood circulation through the body. There is autism among horses believe it or not (isolation, poor feeding, etc). Veterinarians connect it to oxygen starvation during gestation or birth. Among humans, the reasons for autism are many. So, not everyone will be helped by HBOT.

Newborn Horses Give Clues to Autism
https://www.ucdavis.edu/news/newborn-horses-give-clues-autism/
"In newborn foals, the disorder known as neonatal maladjustment syndrome or dummy foal syndrome occurs in only 3 to 5 percent of live births... For years, the syndrome has been attributed to hypoxia — insufficient oxygen during the birthing process. Typically, when a foal’s brain is deprived of oxygen, the resulting effects include mental deficits, abnormal behavior, blindness and even seizures. And, as in human babies, much of the damage is serious and permanent"

- if not treated with HBOT [Fo2]. A parent on one of the boards shared a story of a girl in Romania who suffered hypoxia during birth and was born blind with other developmental problems. After the first HBOT round, she began to see. The parents were so excited that ended up doing 3 rounds of dives, seeing positive results from each one of them.

i-jerry
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Re: My supplement/drug list for ASD

Postby i-jerry » Tue Apr 18, 2017 6:31 pm

FatherOf2 wrote:
i-jerry wrote:Hi fo2, many thanks for the super useful post. We are starting HBOT 1.3 ata 4 weeks ago, 1 hr per day and 5 days a week. in the 20 hrs hbot i didn't see any positive from my son(5.5 yr), but hyper, glue ear(both of us) and yeast problem. I see your son has big progress by using hbot and may i ask which protocol did you use and how long have you notice the progress? Thanks in advance

We used 1.5 ata 100% oxygen inside the whole chamber (no oxygen mask needed, the whole body breathes oxygen). The chamber was made by Sechrist. We supplemented with Amphotericin B starting the second week. We saw intermittent gains during the first 15 dives, then behaviors got worse (dives 15-25) due to yeast, then steady gains on dives 25-40. Another waves of gains came 2 months after stopping HBOT. Some people don't see gains during HBOT but see them 2-3 weeks after stopping HBOT. It has something to do with the body reacting to stopping the oxygen as an injury and mobilizing stem cells to repair. These stem cells start growing blood vessels to continue the elevated oxygen supply to all parts of the body (muscles, brain, etc). That is why HBOT is used by athletes to repair their muscle injuries, or diabetes patients to grow blood vessels into affected areas such as legs (FDA approved HBOT for this purpose). Some people don't see any changes depending on the ASD cause. In my son's case, HBOT helped probably because my son's autism is caused by a lack of oxygen supply into brain (he had low RBC, he had a bruise on his head from the c-section delivery, he fell at age 1.5 with blood coming out his ears). I have read other parents who claim that their child's autism was caused by head bruising during delivery (there is a medical term for it - Cephalohaematoma). There is another boy in my son's school, who is also autistic and has exactly the same traits as my son (hand flapping, sensitivity to noise - closing his ears, anxiety, limited interests and OCD - likes to read labels, pale and thin, etc). His autism was caused by complications at birth, which required to surgically remove one of his lungs, which caused poor blood circulation through the body. There is autism among horses believe it or not (isolation, poor feeding, etc). Veterinarians connect it to oxygen starvation during gestation or birth. Among humans, the reasons for autism are many. So, not everyone will be helped by HBOT.


Hi fo2, many thanks for your reply. I have much better understanding on HBOT now. We are hoping hbot could reduce his inflammation in his brain. I will definitely keep doing it and see the result after 40 sessions. I could feel he talks more when we are doing hbot and hyper( jumping,running with flapping hand once we finish). But he could sit down and play his lego or write math practise book with me within 1 hr or even longer. maybe this is the most positive thing after doing hbot.
May i ask do you know does HBOT brings language to some kids? My son's biggest issue is language. We are using different languages at home and school. He understands both languages but talks more at home with very limited topic (and always relate with numbers). He will stop a topic when i ask him something new and becomes angry. We are expecting more language from him with hbot. many thanks, Jerry

FatherOf2
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Re: My supplement/drug list for ASD

Postby FatherOf2 » Tue Apr 18, 2017 10:30 pm

i-jerry, unfortunately language is the area where HBOT didn't bring significant gains in my son, but other kids may have reacted differently. We saw mostly higher awareness, better following commands, understanding 2 and 3 step directions, better memory. Language mostly improved from MCT oil, Luteolin, Goldenseal, Lamictal, Galantamine and Namenda.

luis
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Re: My supplement/drug list for ASD

Postby luis » Thu Apr 20, 2017 10:27 am

Fantastic post, Fo2 ! Thank you very much for you effort. I'll try to do my son's list, but it will take some time.

Can you answer me if "DA" means dopamine in your post ? (Sorry for the dumb question.)

FatherOf2
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Re: My supplement/drug list for ASD

Postby FatherOf2 » Thu Apr 20, 2017 2:28 pm

luis wrote:Fantastic post, Fo2 ! Thank you very much for you effort. I'll try to do my son's list, but it will take some time.

Can you answer me if "DA" means dopamine in your post ? (Sorry for the dumb question.)

Yes, DA means dopamine. I have noticed that some supplements increase irritability and aggression in my son. I correlated their action to MAO inhibition, which results in higher levels of neurotransmitters. My son already has deficiency in MAO enzyme due to his 'warrior gene'. On top of that, he has increased VMAT1 expression due to a homozygous mutation in SLC18A1, which also increases monoamine neurotransmitters and makes him more likely to develop schizophrenia. That is why I am keeping him away from dopamine, which is a known trigger of schizophrenia, mania and psychosis. It has been very hard to find supplements that work on my son without making him more irritable and aggressive. I haven't tried all things on my list. The list was intended to include all supplements and drugs that are commonly used to treat the mentioned symptoms - sort of cheat sheet or collective wisdom sheet. It will grow over time as I add more things to it based on articles and posts I have read.

luis
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Re: My supplement/drug list for ASD

Postby luis » Fri Apr 21, 2017 9:04 am

Fo2, may I ask how old is you son ? Mine is 16 and his anger (even aggression) issues started with puberty.

I could suggest Ionic Lithium, liquid, from New Beginnings Nutrition. Its absorption is much more great than any lithium in capsules. Also, lithium is necessary for B12 absorption.

FatherOf2
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Re: My supplement/drug list for ASD

Postby FatherOf2 » Fri Apr 21, 2017 9:15 am

luis wrote:Fo2, may I ask how old is you son ? Mine is 16 and his anger (even aggression) issues started with puberty.

I could suggest Ionic Lithium, liquid, from New Beginnings Nutrition. Its absorption is much more great than any lithium in capsules. Also, lithium is necessary for B12 absorption.

He is 8. Aggression and SIB started around 2.5, after we gave DMG. He started banging his head on the floor and tantruming the first day we gave DMG, never tantrumed or self injured before that. He was severe at that time, nonverbal. Now aggression manifests in hitting us or teachers if he doesn't want to do something. But he is verbal now and understands that this is a wrong thing to do. I can discuss it with him and he promises never to do it again. We do ABA a lot. Aggression typically happens a day or two after he eats a lot of candies (probably blood sugar drops after being used to high sugar load) or when we introduce a new supplement, which affects his blood sugar level or neurotransmitters. Thanks for the lithium advice.


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