Our Fecal Transplant Experience

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dabaxter
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Our Fecal Transplant Experience

Postby dabaxter » Fri Jul 29, 2011 9:23 am

Our son was given a fecal transplant yesterday. It is too soon to tell if there will be a difference yet.
We had my son's younger brother tested via CDSA and blood work. His stool profile suggest some inflammation, so he was rejected.
We had a friends son tested and his CDSA seemed as bad as my son. So he was rejected.
After much prayer, we approached another parent at church and had their son tested. His stool profile was good, so we finally scheduled the procedure.
We gave Vancomycin and Diflucan for a few days leading up to the procedure, which were stopped the day before.
We gave Prilosec the morning of the procedure.
We saw the best imaginative somewhat normal play we've ever seen from my son in the bathtub that morning, likely from the use of the Vancomycin.
The doctor had prescribed a sedative, so my son would not fight putting the nasogastric tube in.
We were responsible for obtaining and prepping the sample so we brought a new blender, medical saline, containers, funnel, coffee filters, gloves, etc.
It wasn't until early afternoon until the donor boy was able to provide a sample. Once that happened we went by and picked it up. Then it was off to the doctor's office.
Late in the afternoon, the doctor told us to go ahead and give the sedative. About 20 minutes later, my son was asleep.
Then it was off to the bathroom across the hall to prep the sample, per the Dr. George Russell protocol. We took medical saline and poop and blended it for 4 minutes. We were supposed to filter the liquid twice through 2 coffee filters, but the filters were not cooperating, so we ended up filtering it through a strainer twice and going with that. It was basically a liquid that had the consistency of chocolate milk. Then it was back across the hall back into the doc's office.
The doc put the tube into the stomach with ease and then verified with a stethoscope that it was in the stomach. He pushed in about 25ml of fecal filtrate and then flushed with medical saline. From putting the tube in to pulling it out took all of about 10 minutes, if even that long.
My son woke up after sleeping about 4 hours a little hung over, ate 5 Whopper patties, a big helping of green beans and then went to sleep. As of this morning, we don't see any improvement as of yet. We'll stay away from antimicrobials and give a little culturelle each day for the time being. We'll see what happens of the next couple of weeks. I'll keep you posted.
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isabelmum
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Re: Our Fecal Transplant Experience

Postby isabelmum » Fri Jul 29, 2011 9:38 am

I am still trying to understand this. Whatever it is I pray you will get great result.

williams_dad
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Re: Our Fecal Transplant Experience

Postby williams_dad » Fri Jul 29, 2011 9:44 am

isabelmum wrote:I am still trying to understand this.

viewtopic.php?f=6&t=25520
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Kastania
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Joined: Tue Apr 07, 2009 9:13 am

Re: Our Fecal Transplant Experience

Postby Kastania » Fri Jul 29, 2011 4:06 pm

dabaxter, I would like to thank you for having the persistance and guts to do this, because if you see good results, I'm sure others will follow your lead. For us parents whose kids have bad bacterial issues, this offers a ray of hope. Please keep us up-dated on what you see.

twinsohmy
Posts: 533
Joined: Fri Apr 10, 2009 4:53 pm

Re: Our Fecal Transplant Experience

Postby twinsohmy » Sat Jul 30, 2011 6:35 am

Kastania wrote:dabaxter, I would like to thank you for having the persistance and guts to do this, because if you see good results, I'm sure others will follow your lead. For us parents whose kids have bad bacterial issues, this offers a ray of hope. Please keep us up-dated on what you see.


Couldn't have said it better myself, praying for great results!!!

amanda NC
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Joined: Fri May 25, 2007 7:41 am

Re: Our Fecal Transplant Experience

Postby amanda NC » Sat Jul 30, 2011 6:04 pm

Also praying for good results. Yes, I am in awe of your persistance. Best of luck!
Amanda, mom of 3

JeniB
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Joined: Thu Sep 04, 2008 10:10 pm

Re: Our Fecal Transplant Experience

Postby JeniB » Sun Jul 31, 2011 12:04 pm

Praying too! waiting anxiously to see how he does.
Jen
(mom of 3)

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dabaxter
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Re: 1 Week Update: Our Fecal Transplant Experience

Postby dabaxter » Thu Aug 04, 2011 3:07 pm

To summarize: The gut is stable and no major changes in behavior.

At the 1 week mark, there has been no major impact on behavior. Some of the OCD and visual stims are still there. We dropped LDN, vinpocetine and carnosine prior and have not restarted. There has not been a noticeable loss of language or cognition. Eczema appears to have improved.

However, there has been no regression to a yeast flare or bacteria flare, so the gut appears stable. We are still on GAPS / SCD and will stay there for a while. We have since added berries and seem to have no problems.

Since we do see some improvement on antibiotics and DNASE B is high, the doc is going to prescribe some penicillin shots, to avoid the gut.

We will retest CDSA and OAT at week 2. If all is still well after 2 weeks, we will do a trial of NAC and then go to DAN protocol chelation with DMSA and ALA.

We are going to try Benfotiamine this weekend.

I'll keep you posted at the 2 week mark.
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dabaxter
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Re: Our Fecal Transplant Experience

Postby dabaxter » Thu Aug 11, 2011 9:35 am

We are at the 2 week mark. Bowel movements aren't stellar, but I think that's due to so many veggies. No diarrhea or blow outs though.
The good thing is no regression on bacteria or yeast flares at all. This is with 1 Culturelle per day and no antimicrobials.
We've been on 80mg befotiamine for the last week, and we started back our remedy. He has had a really nice week with language, cognition and social.
Remedies in the past have caused more stimming such as hand flapping. So far this is not the case.
However, minor OCD with fans and holding/twiddling 2 of the same item remains.
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JeniB
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Re: Our Fecal Transplant Experience

Postby JeniB » Thu Aug 11, 2011 9:38 am

That sounds great to me. Let us know how it progresses.
Jen
(mom of 3)

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dabaxter
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Re: Our Fecal Transplant Experience

Postby dabaxter » Mon Aug 15, 2011 10:10 am

Bowel movements are still very good. No diarrhea. Still only taking 1 culturelle per day and no antimicrobials.

The OCD and holding 2-3 tinker toys and twiddling remains.

We are sending off urine and stool samples today.
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dabaxter
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Re: Our Fecal Transplant Experience

Postby dabaxter » Sun Aug 21, 2011 9:14 am

At the 3 1/2 week mark, still no bacteria flares or yeast flares, all with no antimicrobials and just 1 culturelle a day. Bowel movements are still really good with no diarrhea or blow outs. Appetite is nice too. Weight is steady with maybe a slow increase.

The existing OCD with fans and twiddling strings or a couple of tinker toys still remains.

We hope to do another later this fall. I'm still too cautious to change where we are on the GAPS / SCD diet right now.
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joy
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Re: Our Fecal Transplant Experience

Postby joy » Sun Aug 21, 2011 3:02 pm

thats fantastic....
~Joy~

dabaxter
Posts: 4049
Joined: Wed Nov 14, 2007 12:50 pm

2 Weeks Post Transplant OAT Results

Postby dabaxter » Mon Aug 29, 2011 11:05 am

Yeast and Fungal Markers
1 Citramalic ≤ 5.0 0.94 0.94
2 5-Hydroxymethyl-2-furoic ≤ 28 0.15 0.15
3 3-Oxoglutaric ≤ 0.46 0.04 0.04
4 Furan-2,5-dicarboxylic ≤ 18 0.71 0.71
5 Furancarbonylglycine ≤ 3.1 0.21 0.21
6 Tartaric ≤ 6.5 2.8 2.8
7 Arabinose ≤ 50 17 17
8 Carboxycitric ≤ 25 2.0 2.0

Malabsorption and Bacterial Markers
9 2-Hydroxyphenylacetic ≤ 0.86 0.65 0.65
10 4-Hydroxyphenylacetic 2.0 - 32 8.0 8.0
11 4-Hydroxybenzoic ≤ 3.0 H 3.4 3.4
12 4-Hydroxyhippuric ≤ 30 30 30
13 Hippuric ≤ 680 248 248
14 3-Indoleacetic 0.60 - 14 2.1 2.1
15 Succinic ≤ 23 2.8 2.8
16 HPHPA (Clostridia marker) ≤ 220 124 124
17 DHPPA (Beneficial bacteria) ≤ 0.59 0.07 0.07

Oxalate Metabolites
18 Glyceric 0.74 - 13 5.6 5.6
19 Glycolic 27 - 221 H 530 530
20 Oxalic 35 - 185 H 553 553

Glycolytic Cycle Metabolites
21 Lactic 2.6 - 48 13 13
22 Pyruvic 0.32 - 8.8 3.9 3.9
23 2-Hydroxybutyric 0.19 - 2.0 H 4.0 4.0

Krebs Cycle Metabolites
24 Succinic ≤ 23 2.8 2.8
25 Fumaric ≤ 1.8 0.64 0.64
26 Malic ≤ 2.3 1.1 1.1
27 2-Oxoglutaric ≤ 96 14 14
28 Aconitic 9.8 - 39 27 27
29 Citric ≤ 597 36 36

Neurotransmitter Metabolites
30 Homovanillic (HVA) 0.49 - 13 2.9 2.9
(dopamine)
31 Vanillylmandelic (VMA) 0.72 - 6.4 1.4 1.4
(norepinephrine, epinephrine)
32 HVA/VMA Ratio 0.23 - 2.8 2.2 2.2
33 5-Hydroxyindoleacetic (5-HIAA) ≤ 11 1.5 1.5
(serotonin)
34 Quinolinic 0.48 - 8.8 2.1 2.1
35 Kynurenic ≤ 4.2 0.85 0.85
36 Quinolinic/5-HIAA Ratio ≤ 2.5 1.5 1.5

Pyrimidines - Folate Metabolism
37 Uracil ≤ 16 H 17 17
38 Thymine ≤ 0.91 0.74 0.74

Ketone and Fatty Acid Oxidation
39 3-Hydroxybutyric ≤ 4.8 H 74 74
40 Acetoacetic ≤ 10 H 407 407
41 4-Hydroxybutyric ≤ 4.7 H 7.0 7.0
42 Ethylmalonic 0.06 - 4.8 1.7 1.7
43 Methylsuccinic ≤ 4.0 1.9 1.9
44 Adipic 0.19 - 6.5 4.9 4.9
45 Suberic ≤ 7.0 2.2 2.2
46 Sebacic ≤ 0.61 0.10 0.10

Nutritional Markers
Vitamin B12
47 Methylmalonic ≤ 5.2 0.89 0.89
Vitamin B6
48 Pyridoxic (B6) ≤ 53 0.99 0.99
Vitamin B5
49 Pantothenic (B5) ≤ 14 2.5 2.5
Vitamin B2 (Riboflavin)
50 Glutaric ≤ 1.4 0.63 0.63
Vitamin C
51 Ascorbic 10 - 200 37 37
Vitamin Q10 (CoQ10)
52 3-Hydroxy-3-methylglutaric ≤ 88 12 12
Glutathione Precursor and Chelating Agent
53 N-Acetylcysteine (NAC) ≤ 0.34 0.03 0.03

Nutritional Markers
Biotin (Vitamin H)
54 Methylcitric ≤ 5.7 0.87 0.87
Indicators of Detoxification
55 Pyroglutamic 13 - 62 38 38
56 Orotic 0.04 - 0.80 0.66 0.66
57 2-Hydroxyhippuric ≤ 1.2 0.78 0.78

Amino Acid Metabolites
58 2-Hydroxyisovaleric ≤ 0.55 0 0.00
59 2-Oxoisovaleric ≤ 2.5 0 0.00
60 3-Methyl-2-oxovaleric ≤ 1.1 0 0.00
61 2-Hydroxyisocaproic ≤ 0.68 0.03 0.03
62 2-Oxoisocaproic ≤ 0.46 0.12 0.12
63 2-Oxo-4-methiolbutyric ≤ 0.33 0.02 0.02
64 Mandelic ≤ 0.30 H 0.61 0.61
65 Phenyllactic ≤ 0.19 0.08 0.08
66 Phenylpyruvic ≤ 4.0 0.66 0.66
67 Homogentisic ≤ 0.61 0.03 0.03
68 4-Hydroxyphenyllactic 0.05 - 1.1 0.41 0.41
69 N-Acetylaspartic ≤ 5.9 2.7 2.7
70 Malonic ≤ 18 6.4 6.4
71 3-Methylglutaric 0.01 - 0.97 H 2.0 2.0

Bone Metabolites
72 Phosphoric 1 439 - 9 732 H 15 104 15104
73 *Creatinine 45 mg/dL
*The creatinine test is performed to adjust metabolic marker results for differences in fluid intake. Urinary creatinine has
limited diagnostic value due to variability as a result of recent fluid intake. Samples are rejected if creatinine is below 20
mg/dL unless the client requests results knowing of our rejection criteria.
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dabaxter
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Joined: Wed Nov 14, 2007 12:50 pm

CDSA 2 Weeks Post Transplant

Postby dabaxter » Mon Aug 29, 2011 11:27 am

Digestion/Absorption
Pancreatic Elastase 2.0 1.3-8.6 micromol/g
Putrefactive SCFAs 430 >= 201 mcg/g

Gut Immunology
Eosinophil Protein X <0.8 <= 7.0 mcg/g
Calprotectin <16 <50mcg/g

Metabolic

Beneficial SCFAs 19.2 >=13.6 micromol/g
n-Butyrate 2.2 >= 2.5 micromol/g
pH 7.4 6.1-7.9
Beta-glucuronidase 4,427 337-4,433 U/g

Secondary Bile Acids
Lithocholic Acid 1.20 0.65-5.21 mg/g
Deoxycholic Acid 1.24 0.67-6.76 mg/g
LCA/DCA Ratio 0.97 0.39-2.07

Bacteriology
14. Mycology
Lactobacillus species *NG
Escherichia coli 4+
Bifidobacterium 3+
alpha haemolytic Streptococcus NP 2+
*NG *NG


Occult Blood Negative
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Kastania
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Joined: Tue Apr 07, 2009 9:13 am

Re: Our Fecal Transplant Experience

Postby Kastania » Mon Aug 29, 2011 11:32 am

dabaxter, those look like very good test results to me, congratulations! Can I ask which labs you used to do the tests?

hyderhari
Posts: 90
Joined: Tue Feb 01, 2011 6:16 pm

Re: Our Fecal Transplant Experience

Postby hyderhari » Mon Aug 29, 2011 11:34 am

The lacto Strains still show as NG. My Son had it as NG also on his Stool test 6 months back. Was this NG also before the procedure?

dabaxter
Posts: 4049
Joined: Wed Nov 14, 2007 12:50 pm

Re: Our Fecal Transplant Experience

Postby dabaxter » Mon Aug 29, 2011 9:40 pm

Kastania wrote:dabaxter, those look like very good test results to me, congratulations! Can I ask which labs you used to do the tests?


The OAT was from Great Plains. The CDSA was from Genova.

Yes. Lactobacillus was low prior, but so was the other 2 categories.

You can really see where I have been leaving off vitamins and minerals though. We've been almost supplement free for months now. We're about to go back on more.
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DRice
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Joined: Sat Dec 17, 2011 10:17 pm

Re: Our Fecal Transplant Experience

Postby DRice » Sat Dec 17, 2011 10:25 pm

I have a son with Autism, how did the Fecal Transplant work out for your son?

Take care,

dabaxter
Posts: 4049
Joined: Wed Nov 14, 2007 12:50 pm

Re: Our Fecal Transplant Experience

Postby dabaxter » Mon Dec 19, 2011 10:12 am

We've done well to avoid yeast and bacteria flares since.
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