'Baffling' Link between Autism and Vinyl Flooring

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BTDT
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'Baffling' Link between Autism and Vinyl Flooring

Postby BTDT » Tue Mar 31, 2009 7:33 pm

Scientists Find 'Baffling' Link between Autism and Vinyl Flooring
Swedish children who live in homes with vinyl floors are more likely to have autism, according to a new study, but what's behind the link is unclear

By Marla Cone and Environmental Health News

Children who live in homes with vinyl floors, which can emit chemicals called phthalates, are more likely to have autism, according to research by Swedish and U.S. scientists published Monday.

The study of Swedish children is among the first to find an apparent connection between an environmental chemical and autism.

The scientists were surprised by their finding, calling it "far from conclusive." Because their research was not designed to focus on autism, they recommend further study of larger numbers of children to see whether the link can be confirmed.

Bernard Weiss, a professor of environmental medicine at University of Rochester and a co-author of the study, said the connection between vinyl flooring and autism "turned up virtually by accident." He called it "intriguing and baffling at the same time."

Experts suspect that genetic and environmental factors combine to cause autism, a neurodevelopmental disorder that has increased dramatically in children over the past 20 years.

In the new study, Swedish families were asked questions about flooring as part of research investigating allergies and indoor air pollutants. Phthalates, used to make soft plastic, have in previous studies been connected to allergies and asthma.

The study was based on surveys that asked a variety of questions related to the indoor environment. Of the study's 4,779 children between the ages of 6 and 8, 72 had autism, including 60 boys.

The researchers found four environmental factors associated with autism: vinyl flooring, the mother's smoking, family economic problems and condensation on windows, which indicates poor ventilation.

Infants or toddlers who lived in bedrooms with vinyl, or PVC, floors were twice as likely to have autism five years later, in 2005, than those with wood or linoleum flooring.

"A greater proportion of children with autism spectrum disorder were reported to have PVC as flooring material in the child's and the parent's bedroom in 2000 compared to children without autism spectrum disorder," the scientists wrote in the journal Neurotoxicology. "Furthermore, children with autism spectrum disorder were reported to live in homes with more condensation on the inside of the windows, which...may be seen as an indicator for deficient ventilation."

Children in the study also were twice as likely to have autism if their mothers smoked cigarettes. The autistic children also were more likely to have asthma.

The lead investigator was Carl-Gustav Bornehag of Karlstad University in Sweden, who in 2004 found a high rate of asthma and allergies among children living in households with dust containing phthalates.

The scientists reported that they do not know if asthma and autism are related, or whether phthalates contributed to the risk of autism by some other mechanism, such as disruption of hormones. Phthalates in animal tests interfere with male hormones and sexual development.

"The data are far from conclusive. They are puzzling, even baffling, and not readily explicable at this time," the scientists wrote in their study. "However, because they are among the few clues that have emerged about possible environmental contributions to autistic disorders, we believe that they should be weighed carefully and warrant further study."

Several scientists who did not participate in the study cautioned that it has too many limitations to draw conclusions, but they suggested that new studies be designed to look for a connection between autism and indoor air pollutants.

Dr. Philip Landrigan, a pediatrician who is director of the Children's Environmental Health Center at Mount Sinai School of Medicine, called the results "intriguing, but in my mind preliminary because they are based on very small numbers." Landrigan said he has "no doubt that environmental exposures are involved in causation of autism," but he suspects the most significant exposures occur not in childhood, but early in pregnancy, "when the basic architecture of the brain is still being established."

The researchers relied on questionnaires and did not measure any chemicals in the homes, which limits the reliability of the findings because they do not know for certain that the children were exposed to phthalates. Previous studies have found that phthalates are common in household dust.

Phthalates are used as softeners in plastic for vinyl flooring as well as other building materials, toys and medical equipment. The chemicals have become increasing controversial in recent years, with Congress last year banning their use in children's products.

The American Chemistry Council, representing chemical companies producing phthalates, said in a statement Monday that the new study does not prove a link between the chemicals and autism. "No other means for assessing these children existed except for the questionnaire and the parent's responses, making this finding rather insignificant," said Chris Bryant, the group's managing director. Autism, he said, "was not systematically analyzed, but just happened to be a question asked five years into the study."

The industry group has said flooring emits "extremely low" levels of phthalates. Because the compounds are heavy molecules with low volatility, they do not tend to evaporate, and wear and tear that might release particles into dust is slight, they said.

Vinyl flooring is commonplace in Sweden, where only about 1 percent of homes have carpeted floors. But it is uncommon in U.S. bedrooms, so it may not be related to autism among American children. However, carpeting contains other contaminants, including pesticides and brominated flame retardants, which have been found to harm brain development in animal tests.

The scientists said their new finding "suggests that studies of other chemical contaminants with endocrine disruptor properties might yield useful insights into the genesis of" autism.

Previously, three studies in California have found a connection between children's exposure to household or agricultural pesticides and autism.

Rates of autism in California have increased seven-fold since 1990, a recent study found. Because genetics do not change that quickly, scientists suspect that chemical pollutants are probably playing a role. But there have been few studies attempting to pinpoint which chemicals, or combination of chemicals.

This article originally ran at Environmental Health News, a news source published by Environmental Health Sciences, a nonprofit media company.

María Luján
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Joined: Sun Jun 25, 2006 5:26 pm

Postby María Luján » Tue Mar 31, 2009 9:22 pm

These are only few examples of the recent research on phtalates and other compounds as endocrine disruptors.
Sci Total Environ. 2008 Oct 1;404(1):26-35. Epub 2008 Jul 15. Links
Occurrence of endocrine-disrupting chemicals in indoor dust.Hwang HM, Park EK, Young TM, Hammock BD.
Department of Civil and Environmental Engineering, University of California, One Shields Ave., Davis, CA 95616, USA.
Human exposure to indoor dust enriched with endocrine-disrupting chemicals released from numerous indoor sources has been a focus of increasing concern. Longer residence times and elevated contaminant concentrations in the indoor environment may increase chances of exposure to these contaminants by 1000-fold compared to outdoor exposure. To investigate the occurrence of semi-volatile endocrine-disrupting chemicals, including PBDEs (polybrominated diphenyl ethers), PCBs (polychlorinated biphenyls), phthalates, pyrethroids, DDT (dichlorodiphenyltrichloroethane) and its metabolites, and chlordanes, indoor dust samples were collected from household vacuum cleaner bags provided by 10 apartments and 1 community hall in Davis, California, USA. Chemical analyses show that all indoor dust samples are highly contaminated by target analytes measured in the present study. Di-(2-ethylhexyl)phthalate was the most abundant (104-7630 microg/g) in all samples and higher than other target analytes by 2 to 6 orders of magnitude. PBDEs were also found at high concentrations (1780-25,200 ng/g). Although the use of PCBs has been banned or restricted for decades, some samples had PCBs at levels that are considered to be concerns for human health, indicating that the potential risk posed by PCBs still remains high in the indoor environment, probably due to a lack of dissipation processes and continuous release from the sources. Although the use of some PBDEs is being phased out in some parts of the U.S., this trend may apply to PBDEs as well. We can anticipate that exposure to PBDEs will continue as long as the general public keeps using existing household items such as sofas, mattresses, and carpets that contain PBDEs. This study provides additional information that indoor dust is highly contaminated by persistent and endocrine-disrupting chemicals

Link

Curr Drug Metab. 2008 May;9(4):269-75. Links
Sulfotransferase inhibition: potential impact of diet and environmental chemicals on steroid metabolism and drug detoxification.Harris RM, Waring RH.
School of Biosciences, University of Birmingham, Birmingham, UK.
The cytosolic sulfotransferase enzymes (SULT isoforms) utilise PAPS (3'-phosphoadenosine-5'-phosphosulfate) as co-factor to transfer sulfonate groups onto a wide range of substrates. SULT1A3 has catecholamines such as dopamine as substrates while SULT 1E1 sulfonates oestrogens. SULT 1A1 sulfonates phenols and also oestrogens at a higher K(m) than SULT 1E1. SULT 2A1 mainly sulfonates DHEA and some steroids, with hydroxy derivatives of polycyclic aromatic hydrocarbons. Studies on these isoforms with a range of environmental chemicals and dietary components have shown that SULT 1A1 is significantly inhibited by flavonoids; all flavones and flavonols with a 3',4'-dihydroxy motif had an IC(50) of < 100 nm against 3 microM 4-nitrophenol as the standard substrate. SULTs 1A3 and 2A1 were less strongly inhibited by flavonoids or isoflavonoids although tricin (3',5'-dimethoxy-4',5,7-trihydroxyflavone is a competitive inhibitor of SULT 1E1 with an inhibition constant of approximately 1 nM. Fruit and vegetable cytosols also inhibit SULT isoforms, as do long-chain alkylphenols and chlorinated phenols. Phthalates (used as plasticisers) inhibited SULTs 1E1 and 2A1. As these environmental contaminants and dietary components all act at the same site, their effects would be expected to be additive and could potentially therefore reduce sulfonation of drugs and lead to altered pharmacological responses.

Int J Hyg Environ Health. 2007 Oct;210(5):623-34.
Phthalates: toxicology and exposure.Heudorf U, Mersch-Sundermann V, Angerer J.
Public Health Department of the City of Frankfurt, Germany.
Phthalates are used as plasticizers in PVC plastics. As the phthalate plasticizers are not chemically bound to PVC, they can leach, migrate or evaporate into indoor air and atmosphere, foodstuff, other materials, etc. Consumer products containing phthalates can result in human exposure through direct contact and use, indirectly through leaching into other products, or general environmental contamination. Humans are exposed through ingestion, inhalation, and dermal exposure during their whole lifetime, including intrauterine development. This paper presents an overview on current risk assessments done by expert panels as well as on exposure assessment data, based on ambient and on current human biomonitoring results. Some phthalates are reproductive and developmental toxicants in animals and suspected endocrine disruptors in humans. Exposure assessment via modelling ambient data give hints that the exposure of children to phthalates exceeds that in adults. Current human biomonitoring data prove that the tolerable intake of children is exceeded to a considerable degree, in some instances up to 20-fold. Very high exposures to phthalates can occur via medical treatment, i.e. via use of medical devices containing DEHP or medicaments containing DBP phthalate in their coating. Because of their chemical properties exposure to phthalates does not result in bioaccumulation. However, health concern is raised regarding the developmental and/or reproductive toxicity of phthalates, even in environmental concentrations.

ChemE
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Joined: Tue Nov 10, 2015 10:31 am

Re: 'Baffling' Link between Autism and Vinyl Flooring

Postby ChemE » Sun Nov 13, 2016 11:32 pm

The researchers found four environmental factors associated with autism: vinyl flooring, the mother's smoking, family economic problems and condensation on windows, which indicates poor ventilation.

Vinyl Flooring Static Electrical Charge Buildup:

b) Walking/crawling over untreated vinyl floor = 250 to 12,000 volts

http://floorcentral.com/carpet-and-rugs ... ty-carpet/

Condensation on cold windows removes moisture from the air and increases electrostatic voltage buildup in the room, especially flooring.

I think strong local electric fields are the primary cause of autism.

https://www.academia.edu/18019528/Evide ... e_antennas

ChemE
Posts: 8
Joined: Tue Nov 10, 2015 10:31 am

Re: 'Baffling' Link between Autism and Vinyl Flooring

Postby ChemE » Sat Nov 19, 2016 1:30 pm

I put a graphic together summarizing my theory/research

https://darkmattersalot.com/2016/11/19/ ... e-residue/

ChemE
Posts: 8
Joined: Tue Nov 10, 2015 10:31 am

Re: 'Baffling' Link between Autism and Vinyl Flooring

Postby ChemE » Fri Nov 25, 2016 7:27 pm

Vinyl Flooring develops up to 12,000 volts. Child is crawling/playing in a strong electric field with lots of surface area.

http://esdsystems.descoindustries.com/w ... idity.html

ChemE
Posts: 8
Joined: Tue Nov 10, 2015 10:31 am

Re: 'Baffling' Link between Autism and Vinyl Flooring

Postby ChemE » Thu Mar 16, 2017 12:44 pm

Link to another graphic. "Oxidative stress" which is implied in many cases of autism and some cancers can be caused by an exchange of electrons, like in RedOx reactions. This graphic shows ways that excess electrons can be exchanged with a child.

https://darkmattersalot.com/2017/03/16/ ... otentials/

raun cesar
Posts: 30
Joined: Thu Mar 02, 2017 5:17 am

Re: 'Baffling' Link between Autism and Vinyl Flooring

Postby raun cesar » Fri Mar 24, 2017 9:59 am

After reading all this....planning to change my vinyls. Just thinking about the effects of increasing radio frequencies on the autism


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