New theory with implications for prevention and treatment

Discuss autism theories, media stories, and efforts to put ASD on the government agenda here.

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LetterRip
Posts: 17
Joined: Tue Oct 19, 2010 12:33 am

New theory with implications for prevention and treatment

Postby LetterRip » Sat Jul 09, 2011 12:25 pm

Hi all,

I've developed a new theory of autism/disease process

"Tight Junction Permeability theory of Disease"
http://www.amazon.com/Junction-Permeabi ... ref=sr_1_1

I've filed the relevant provisional patent, and have just published the extremely rough manuscript (it contains essentially the information needed to describe my theory for a patent examiner and interested lay person - is a bit sparse on references).

Things that are explained by my theory are

1) Changes in prevalence rates
2) Why different individuals have different comorbidities
3) Why particular allergies are comorbid
4) Why particular deficiencies are comorbid
5) Why particular autoimmune diseases are comorbid
6) Why particular neurological diseases are comorbid
7) Why the individual has specific food preferences
8) Why particular pregnancy complications and after birth events are important
9) Environmental factors
10) Twin studies data
11) Why certain treatments work for some individuals and not others
12) specific recommended treatment options that should result in enormous improvements

If you are interested the ebook version will be published later today on amazon. However I can make the google document that it is based off of available for free for those interested. If you wish to see the document however, I have a few requests

1) I have a survey on specific comorbidities that would be good to have you fill out; it requests information on the individuals allergies and intolerances; comorbid autoimmune and neurological diseases; food preferences and dislikes; known vitamin/mineral and other nutritional deficiencies; also a little bit of medical history (sicknesses, immunizations and some medication usage); also a bit of history of the pregnancy (maternal morning sickness and specific food intolerances and preferences)

2) That if you use the treatment I describe that you keep a log of specifics of usage and a progress report that be provided to me.

3) That if my treatment results in drastic improvement or cure of your child/relation/etc. that you consider making a donation to me. The donations will be used primarily for me to do further research and accomplish specific social, health, educational and other public benefit goals.

4) Permission to use you as a reference to media, etc. as proof of effectiveness.


Note that you don't have to agree to the 4 in advance, only if after you read the manuscript and decide that it has merit. Also you don't have to agree to any of them, you can agree to all 4 or none, but would appreciate your agreeement.
Last edited by LetterRip on Sat Jul 09, 2011 1:14 pm, edited 1 time in total.

Kenny V
Posts: 1282
Joined: Tue Apr 11, 2006 10:22 am

Re: New theory with implications for prevention and treatment

Postby Kenny V » Sat Jul 09, 2011 12:45 pm

LetterRip wrote:Hi all,

I've developed a new theory of autism/disease process


If you are interested the ebook version will be published later today on amazon. However I can make the google document that it is based off of available for free for those interested. If you wish to see the document however, I have a few requests

1) I have a survey on specific comorbidities that would be good to have you fill out; it requests information on the individuals allergies and intolerances; comorbid autoimmune and neurological diseases; food preferences and dislikes; known vitamin/mineral and other nutritional deficiencies; also a little bit of medical history (sicknesses, immunizations and some medication usage); also a bit of history of the pregnancy (maternal morning sickness and specific food intolerances and preferences)

2) That if you use the treatment I describe that you keep a log of specifics of usage and a progress report that be provided to me.

3) That if my treatment results in drastic improvement or cure of your child/relation/etc. that you consider making a donation to me. The donations will be used primarily for me to do further research and accomplish specific social, health, educational and other public benefit goals.

4) Permission to use you as a reference to media, etc. as proof of effectiveness.


Note that you don't have to agree to the 4 in advance, only if after you read the manuscript and decide that it has merit. Also you don't have to agree to any of them, you can agree to all 4 or none, but would appreciate your agreeement.



O ty cant wait please share all your work with us
Many of us been wondering about this stuff a long time . Its great to see someone come along and lend a few answers to so many un answered Q's ... a true God send

with your request for personal info please see
viewtopic.php?f=5&t=25472
Always Hope For Recovery

LetterRip
Posts: 17
Joined: Tue Oct 19, 2010 12:33 am

Re: New theory with implications for prevention and treatment

Postby LetterRip » Sat Jul 09, 2011 12:48 pm

Hi Kenny,

you sure that is the correct link? Doesn't seem relevant to the topic at hand. If you'd like to view the paper

email LetterRip AT gmail DOT com

and will provide you the link via google doc.

Tom M.
LetterRip

Kenny V
Posts: 1282
Joined: Tue Apr 11, 2006 10:22 am

Re: New theory with implications for prevention and treatment

Postby Kenny V » Sat Jul 09, 2011 1:03 pm

LetterRip wrote:Hi Kenny,

you sure that is the correct link? Doesn't seem relevant to the topic at hand. If you'd like to view the paper

email LetterRip AT gmail DOT com

and will provide you the link via google doc.

Tom M.
LetterRip


No its relevant …Bill hasn’t caught up yet.. just giving folks an early heads up :wink:



Just post your work like you promised and we all can view it .
But please NO! “ However” we all Just like to see the news straight. without the hoops and yo yo’s


You wrote:
can make the google document that it is based off of available for free for those interested. If you wish to see the document however, I have a few requests
Always Hope For Recovery

LetterRip
Posts: 17
Joined: Tue Oct 19, 2010 12:33 am

Re: New theory with implications for prevention and treatment

Postby LetterRip » Sat Jul 09, 2011 1:07 pm

I'm pretty sure you had to have posted the wrong link, there really is nothing there - the title is 'topic moved #2' and something about 'spats between biomed parents' ??? I've no clue at all what it means, but really has zero info related to this thread afaik.

LetterRip
Posts: 17
Joined: Tue Oct 19, 2010 12:33 am

Re: New theory with implications for prevention and treatment

Postby LetterRip » Sat Jul 09, 2011 1:09 pm

Kenny,

Just post your work like you promised and we all can view it .
But please NO! “ However” we all Just like to see the news straight. without the hoops and yo yo’s


Hmm not sure what promise or hoops you are talking about. It will be up on amazon shortly, those who don't wish to go via amazon can email me to view it for free.

Kenny V
Posts: 1282
Joined: Tue Apr 11, 2006 10:22 am

Re: New theory with implications for prevention and treatment

Postby Kenny V » Sat Jul 09, 2011 1:20 pm

please email me yure abstract and or research paper without any strings attached or whatever relevant thing you have to help treat autism

thanks

Kenny V



LetterRip wrote:Kenny,

Just post your work like you promised and we all can view it .
But please NO! “ However” we all Just like to see the news straight. without the hoops and yo yo’s


Hmm not sure what promise or hoops you are talking about. It will be up on amazon shortly, those who don't wish to go via amazon can email me to view it for free.
Always Hope For Recovery

Kari
Posts: 1148
Joined: Wed Jul 08, 2009 3:37 pm

Re: New theory with implications for prevention and treatment

Postby Kari » Sat Jul 09, 2011 1:52 pm

Hi Tom. Most of us on here have heard plenty of theories about the cause and cure of autism. Can you give us a little more info? I'm always interested in learning about other possibilities, but I'm sure many reading this will wonder why we should consider the theory you've written about when there are so many others. That's not to discount it. Many of us have tried lots of things with our kids and have done lots of research on our own. Is this truly something new, or something that ties together things we already know? Are you a parent, a doctor, a researcher?

LetterRip
Posts: 17
Joined: Tue Oct 19, 2010 12:33 am

Re: New theory with implications for prevention and treatment

Postby LetterRip » Sat Jul 09, 2011 2:44 pm

Kari, sure here is a very brief overview,

The core of the theory is that damage/dysfunction of the tight junctions of the blood brain barrier (and other tight junctions such as those surrounding innervation to organs) results in nutrients that are actively transported across the BBB 'leaking out' of the Interstitial Fluid (ISF) back to the blood. This includes many components needed for the synthesis of of key neurotransmitters (particularly L-DOPA/dopamine/epinephrine/norepinephrine the 'dopamine path' and melatonin/serotonin + creatine/adenosine path) mylenation (biotin) and protection/repair of oxidative damage (Glutathione). This results in a biosynthesis path deficiency which is often comorbid with a blood deficiency of the relevant nutrients. The pattern of and intensity of the damage (as well as timing) and degree of deficiency determines the particular neurological disease and pathology encountered.

For many neurological diseases the occurrence of oxidative damage is primarily during fetal development (hypoxia + low glutathione) although often with later developmental damage. Oxidative damage to the tight junctions of the barriers surrounding organ innervation is the reason for comorbid auto immune diseases - and general oxidative damage can result in other diseases comorbidites that will be normally distributed (so you will see seemingly random commordibity with a large number of congenital diseases). Certain events after birth can result in further nutrient deficiency and/or oxidative damage and/or other causes of increased leakiness (ie low blood pressure). Also the demands due to growth will exacerbate deficiencies.

The brain has a compensatory mechanism for low dopamine - cortisol - which tightens the junctions and reduces their leakiness in a global manner, it also stimulates tryptophan catabolism because dopamine path competes with tryptophan path for nutrients and dopamine is more important for survival. This catabolism of tryptophan results in reduction of serotonin production (leading to comorbid depression, anxiety, anger, sleep disorders and numerous other issues related to serotonin path deficiency and increased autoimmune response). The compensation mechanism can result in undamaged areas gaining superior ability (savants, heightened sense or senses - smell, touch, hearing) as these brain areas will have a relative excess neurotransmitter and other nutrient availability to normal.

The results of twin studies are primarily due to shared vs unshared placenta, not genetics (as is clear when we look at dichorionic studies versus monochorionic for the few times they have been done ie for schizophrenia).

As to whether this is 'truely something new' - I'm fairly sure that it is. (Actually it is in truth four new theories - one for neurological diseases; another for autoimmune; another for allergies; and another related to nutritional effects of nutrient density)

LetterRip
Posts: 17
Joined: Tue Oct 19, 2010 12:33 am

Re: New theory with implications for prevention and treatment

Postby LetterRip » Sat Jul 09, 2011 4:41 pm

Note that this theory lets us play '7 degrees of kevin bacon' with diseases :)

For instance Seasonal Affective Disorder

Low sunlight -> low vitamin D -> vitamin D deficient anemia and oxidative damage to tight junctions unrepaired -> low dopamine -> high cortisol -> low tryptophan -> low melatonin (sleep dysregulation) and low serotonin (depression)

Or lets play Post Traumatic Stress Disorder

shockwave from concussion -> trauma to tight junctions -> low dopamine -> high cortisol -> low tryptophan -> low melatonin and low serotonin -> depression/anger/assorted mental disorders depending on where the damage occurred

I can play this game with pretty much any neurological disease and a huge host of diseases without a suspected neuro component.

mimicry
Posts: 2143
Joined: Fri Jan 15, 2010 6:57 pm

Re: New theory with implications for prevention and treatment

Postby mimicry » Sat Jul 09, 2011 8:28 pm

Don't mind Kenny, he's paranoid of newcomers. I've been really busy lately, hopefully I can look at this better on Thursday. Not all of us feel we have solved autism....

JeniB
Posts: 5021
Joined: Thu Sep 04, 2008 10:10 pm

Re: New theory with implications for prevention and treatment

Postby JeniB » Sat Jul 09, 2011 10:15 pm

what do you feel triggers it? I will say this, the cord was wrapped around my son's neck a few times, he was born blue but checked out o.k. shortly after birth. I've read some interesting stuff on clamping of the umbilical cord being to blame for the right sided weakness that we had. Apparently this is a fairly new practice during delivery within the last 30 years or so. Chelation has done an awful lot for us however and I'm curious how this applies to treatment/cause.
Jen
(mom of 3)

iherb referral code: HOF516
save $5 on first purchase

Kenny V
Posts: 1282
Joined: Tue Apr 11, 2006 10:22 am

Re: New theory with implications for prevention and treatment

Postby Kenny V » Sat Jul 09, 2011 10:28 pm

LetterRip wrote:Note that this theory lets us play '7 degrees of kevin bacon' with diseases :)

I can play this game with pretty much any neurological disease and a huge host of diseases without a suspected neuro component.


ITS NOT A GAME
STILL WAITING FOR SOME USEFULL INFO . PLEASE POST IT WHEN YA HAVE IT READY AND AVAILIBLE FOR US TO LOOK IT OVER THANKS
Kv
Always Hope For Recovery

williams_dad
Posts: 2967
Joined: Sun Feb 12, 2006 6:47 am

Re: New theory with implications for prevention and treatment

Postby williams_dad » Sat Jul 09, 2011 10:41 pm

I have some questions

* has your theory been peer reviewed
* what qualifications do you have
* why do you need a patent, surely you have copyright on your book / manuscript
* what field experience do you base your new theory on

WD
http://spectrumsleuth.fr.yuku.com/forums/11/General/General

LetterRip
Posts: 17
Joined: Tue Oct 19, 2010 12:33 am

Re: New theory with implications for prevention and treatment

Postby LetterRip » Sat Jul 09, 2011 11:03 pm

* has your theory been peer reviewed
* what qualifications do you have
* why do you need a patent, surely you have copyright on your book / manuscript
* what field experience do you base your new theory on


I've had relevant specialists (immunology, neuroscience, psychology) look and so far no one has been able to poke holes in it.
I don't have qualifications - I've done quite a bit of neuroscience coursework, but that was many moons in the past.
Patent and copyright are entirely different fields of IP law. If would have failed to patent it then someone else might have (while my disclosure should be enough to count as prior art and invalidate patents based on it by others - the reality is that patent clerks are overworked and getting the patents myself is far less work than fighting through the courts invalidating patents based on my work). Also my patents aren't 'just' for autism treatment.

Regarding treatments - I've actually been able to predict numerous treatments - including ones that everyone else has zero clue why it works, since the mechanism should be exactly the same for all related diseases there isn't any apriori reason it shouldn't work.

Kenny V,

I provided plenty of useful info, I lay things out in quite a bit of detail in my book - but the core of the theory that I've provided here completely explains all that one needs for basic understanding.

Yes it isn't 'a game' I was just making a point how well this can explain many unexplained diseases in a trivially obvious manner once you accept the core precepts.

LetterRip
Posts: 17
Joined: Tue Oct 19, 2010 12:33 am

Re: New theory with implications for prevention and treatment

Postby LetterRip » Sat Jul 09, 2011 11:13 pm

jeni8,

what do you feel triggers it? I will say this, the cord was wrapped around my son's neck a few times, he was born blue but checked out o.k. shortly after birth. I've read some interesting stuff on clamping of the umbilical cord being to blame for the right sided weakness that we had. Apparently this is a fairly new practice during delivery within the last 30 years or so. Chelation has done an awful lot for us however and I'm curious how this applies to treatment/cause.


It is 'hypoxia with glutathione and other important antioxidant deficiency' - the damage from hypoxia/reperfusion can be mostly prevented IF there is adequate glutathione, melatonin, vitamin K, and vitamin D - if not than you get significantly more oxidative damage to the tight junction. One of the things depleting glutathione levels is acetaminophen; one of the things depleting melatonin and vitamin K levels is antibiotics (melatonin and vitamin K are some of the useful nutrients produced by gut bacteria), deficient vitamin D is usually a lack of sunlight.

Chelation therapy can be useful for some folks - depends on heavy metal exposure.

Kenny V
Posts: 1282
Joined: Tue Apr 11, 2006 10:22 am

Re: New theory with implications for prevention and treatment

Postby Kenny V » Sat Jul 09, 2011 11:23 pm

LetterRip wrote:jeni8,

what do you feel triggers it? Chelation has done an awful lot for us however and I'm curious how this applies to treatment/cause.


Chelation therapy can be useful for some folks - depends on heavy metal exposure.


Thanks for your insight you should write a book or something. So when ya gona break bread with us and share something useful.
TIA
KV
Always Hope For Recovery

dabaxter
Posts: 4052
Joined: Wed Nov 14, 2007 12:50 pm

Re: New theory with implications for prevention and treatment

Postby dabaxter » Sun Jul 10, 2011 12:35 am

LetterRip wrote:12) specific recommended treatment options that should result in enormous improvements


ok LR,
What are the recommended treatment options?
$5 off iherb.com. Use:REW815/$5 off pureformulas.com Use:RJNXCX

LetterRip
Posts: 17
Joined: Tue Oct 19, 2010 12:33 am

Re: New theory with implications for prevention and treatment

Postby LetterRip » Sun Jul 10, 2011 12:47 am

1) take nutrients, foods, drugs, and/or hormones that tighten the junction
2) take foods/probiotics/antioxidants that target tight junction repair and protection - megadosing can be beneficial
3) take foods/probiotics/nutrients relevant to the pathways identified (Glutathione; biotin; dopamine/serotonin) - megadosing can be beneficial
4) optional - take nootropics
5) optional - take foods/nutrients that improve dopamine recycling

williams_dad
Posts: 2967
Joined: Sun Feb 12, 2006 6:47 am

Re: New theory with implications for prevention and treatment

Postby williams_dad » Sun Jul 10, 2011 1:44 am

you know ...
many parents here are spending a small fortune already on
nutrients, foods, drugs, and/or hormones

I think if anyone is expecting them to spend more then surely they ( the parents ) have a moral right to know what the therapy is and what the outcomes are expected to be

WD
http://spectrumsleuth.fr.yuku.com/forums/11/General/General


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