Efficacy of melatonin and CoQ10 on PA induced ASD model

Discuss autism theories, media stories, and efforts to put ASD on the government agenda here.

Moderator: ModeratorBill

Forum rules
Please limit quotes from articles to five paragraphs. Also, researchers may post study information here.
kulkulkan
Posts: 2075
Joined: Tue Mar 13, 2012 1:37 pm

Efficacy of melatonin and CoQ10 on PA induced ASD model

Postby kulkulkan » Tue Mar 04, 2014 1:52 pm

Rodent study - very high doses.

Selected biomarkers as predictive tools in testing efficacy of melatonin and coenzyme Q on propionic acid - induced neurotoxicity in rodent model of autism.
Al-Ghamdi M, Al-Ayadhi L, El-Ansary A.
Abstract
BACKGROUND:
Exposures to environmental toxins are now thought to contribute to the development of autism spectrum disorder. Propionic acid (PA) found as a metabolic product of gut bacteria has been reported to mimic/mediate the neurotoxic effects of autism. Results from animal studies may guide investigations on human populations toward identifying environmental contaminants that produce or drugs that protect from neurotoxicity. Forty-eight young male Western Albino rats were used in the present study. They were grouped into six equal groups 8 rats each. The first group received a neurotoxic dose of buffered PA (250 mg/Kg body weight/day for 3 consecutive days). The second group received only phosphate buffered saline (control group). The third and fourth groups were intoxicated with PA as described above followed by treatment with either coenzyme Q (4.5 mg/kg body weight) or melatonin (10 mg/kg body weight) for one week (therapeutically treated groups). The fifth and sixth groups were administered both compounds for one week prior to PA (protected groups). Heat shock protein70 (Hsp70), Gamma amino-butyric acid (GABA), serotonin, dopamine, oxytocin and interferon gamma-inducible protein 16 together with Comet DNA assay were measured in brain tissues of the six studied groups.
RESULTS:
The obtained data showed that PA caused multiple signs of brain toxicity revealed in depletion of GABA, serotonin, and dopamine, are which important neurotransmitters that reflect brain function, interferon gamma-inducible protein 16 and oxytocin. A high significant increase in tail length, tail DNA% damage and tail moment was reported indicating the genotoxic effect of PA. Administration of melatonin or coenzyme Q showed both protective and therapeutic effects on PA-treated rats demonstrated in a remarkable amelioration of most of the measured parameters.
CONCLUSION:
In conclusion, melatonin and coenzyme Q have potential protective and restorative effects against PA-induced brain injury, confirmed by improvement in biochemical markers and DNA double strand breaks

noelm
Posts: 404
Joined: Tue Jun 21, 2011 2:50 pm

Re: Efficacy of melatonin and CoQ10 on PA induced ASD model

Postby noelm » Sat Mar 22, 2014 11:38 am

You won't be able to give comparable doses to human beings (and this is the thing I REALLY hate about these studies). I have seen so many such studies in Autism and IBD, that I really wonder how peer review is done.
iHerb code BMV549
$5/$10 off on $20/$40 first order
uBiome 10% off http://bit.ly/1xYWjbG

luis
Posts: 257
Joined: Thu Sep 25, 2008 8:42 pm

Re: Efficacy of melatonin and CoQ10 on PA induced ASD model

Postby luis » Mon Mar 16, 2015 4:26 pm

Interesting !

Does anyone wonder how CoQ10 could reduce proprionic acid ?

kulkulkan
Posts: 2075
Joined: Tue Mar 13, 2012 1:37 pm

Re: Efficacy of melatonin and CoQ10 on PA induced ASD model

Postby kulkulkan » Mon Mar 16, 2015 9:58 pm

Coq10 didn't reduce proprionic acid - instead it reduced or minimized the neurotoxic effects of proprionic acid in this rat model. Almost all antioxidants appear to be neuroprotective in rat studies (minimize injury) and in this case, therapeutic (can repair) as well. The Coq10 dosage isn't that high in this study (4.5mg/kg) but the melatonin one is quite high. Aside from dosage another consideration is timing - very likely the injury in ASD may have been years ago, so therapeutic effect might not be as profound as in this rat study.


Return to “Autism Articles, Studies & Politics”