Vitamin D status and efficacy in ASD

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kulkulkan
Posts: 2075
Joined: Tue Mar 13, 2012 1:37 pm

Vitamin D status and efficacy in ASD

Postby kulkulkan » Fri Apr 17, 2015 4:04 pm

We were able to get the level to 49 ng/ml but haven't supplemented Vitamin D in a while. Keeping it over 40ng/ml per below makes sense. Need to restart again to ensure it stays high. 80% of those who supplemented had significantly improvements per below (uncontrolled part of the study).

http://www.ncbi.nlm.nih.gov/pubmed/25876214

Nutr Neurosci. 2015 Apr 15. [Epub ahead of print]
Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children.
Saad K, Abdel-Rahman AA, Elserogy YM, Al-Atram AA, Cannell JJ, Bjørklund G, Abdel-Reheim MK, Othman HA, El-Houfey AA, Hashem EA, Abd El-Aziz NH, Abd El-Baseer KA, Ahmed AE, Ali AM.
Abstract
Objectives Autism spectrum disorder (ASD) is a developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and non-verbal communication, and stereotyped patterns of interests and activities. Vitamin-D deficiency was previously reported in autistic children. However, the data on the relationship between vitamin D deficiency and the severity of autism are limited. Methods We performed a case-controlled cross-sectional analysis conducted on 122 ASD children, to assess their vitamin D status compared to controls and the relationship between vitamin D deficiency and the severity of autism. We also conducted an open trial of vitamin D supplementation in ASD children.

Results Fifty-seven percent of the patients in the present study had vitamin D deficiency, and 30% had vitamin D insufficiency. The mean 25-OHD levels in patients with severe autism were significantly lower than those in patients with mild/moderate autism. Serum 25-OHD levels had significant negative correlations with Childhood Autism Rating Scale (CARS) scores. Of the ASD group, 106 patients with low-serum 25-OHD levels (<30 ng/ml) participated in the open label trial. They received vitamin D3 (300 IU/kg/day not to exceed 5000 IU/day) for 3 months. Eighty-three subjects completed 3 months of daily vitamin D treatment. Collectively, 80.72% (67/83) of subjects who received vitamin D3 treatment had significantly improved outcome, which was mainly in the sections of the CARS and aberrant behavior checklist subscales that measure behavior, stereotypy, eye contact, and attention span.

Conclusion Vitamin D is inexpensive, readily available and safe. It may have beneficial effects in ASD subjects, especially when the final serum level is more than 40 ng/ml.

Trial registration number UMIN-CTR Study Design: trial Number: R000016846.

KEYWORDS:
Autism; Children; Neurodevelopmental; Vitamin D

Shaine7
Posts: 11
Joined: Thu Dec 11, 2014 3:17 am

Re: Vitamin D status and efficacy in ASD

Postby Shaine7 » Fri Apr 17, 2015 6:44 pm

Nothing on D2?
Last edited by Shaine7 on Fri Apr 17, 2015 6:45 pm, edited 1 time in total.

kulkulkan
Posts: 2075
Joined: Tue Mar 13, 2012 1:37 pm

Re: Vitamin D status and efficacy in ASD

Postby kulkulkan » Fri Apr 17, 2015 6:45 pm

Shaine7 wrote:D3?


Yes.

Josie
Posts: 393
Joined: Mon Jun 11, 2012 1:35 am

Re: Vitamin D status and efficacy in ASD

Postby Josie » Sat Apr 18, 2015 1:37 pm

The recommended form of vitamin D is vitamin D3 or cholecalciferol. This is the natural form of vitamin D that your body makes from sunlight. Supplements are made from the fat of lambs' wool.

Many supplements contain vitamin D as vitamin D2 or calciferol. It's derived from irradiated fungus. Because this is not the form of vitamin D naturally made by your body, WebMD nutritionist Kathleen M. Zelman, MPH, RD, recommends using the D3 form for those taking vitamin D supplements.

Research suggests that vitamin D could play a role in the prevention and treatment of a number of different conditions, including type1 and type 2 diabetes, hypertension, glucose intolerance, and multiple sclerosis




http://www.webmd.com/food-recipes/vitamin-d-deficiency

http://www.webmd.com/osteoporosis/featu ... -d-is-best

Josie
Posts: 393
Joined: Mon Jun 11, 2012 1:35 am

Re: Vitamin D status and efficacy in ASD

Postby Josie » Fri May 22, 2015 5:19 am

Vitamin K2 and Vitamin D supplementation

Mega dosing With Vitamin D is not a good thing if you are deficient in Vitamin K2.

some people who are mega-dosing vitamin D are ending up with kidney stones and stiff arthritic joints because the calcium is being stored in the wrong place. These people are deficient in vitamin K and vitamin D can cause an even further deficiency since they’re somewhat antagonistic.

In enters vitamin K2… Vitamin K2 is a calcium regulator in the body. It puts calcium where it should be (teeth and bones) and takes it out of places it shouldn’t (arteries, kidneys, tissue, etc.) In fact, this was the elusive “X factor” that Dr. Weston A. Price said was present in the diets of healthy cultures around the world, in combination with vitamin A and D.


http://www.mamanatural.com/why-vitamin- ... to-get-it/

Vitamin K1 and K2 are not the same. Vitamin K1 is mainly responsible for blood clotting and serves a different function than K2. K1 can be converted to K2 by the bacteria in our gut but that’s usually a challenge for those who have taken antibiotics.


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