Carnitine reverses regressive Autism: a case study

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kulkulkan
Posts: 2075
Joined: Tue Mar 13, 2012 1:37 pm

Carnitine reverses regressive Autism: a case study

Postby kulkulkan » Thu May 07, 2015 10:57 pm

Improvement of regressive autism symptoms in a child with TMLHE deficiency following carnitine supplementation.
Ziats MN, et al. Am J Med Genet A. 2015.

Abstract
Disorders of carnitine biosynthesis have recently been associated with neurodevelopmental syndromes such as autism spectrum disorder (ASD). A 4-year-old male with autism and two episodes of neurodevelopmental regression was identified to have a mutation in the TMLHE gene, which encodes the first enzyme in the carnitine biosynthesis pathway, and concurrent carnitine deficiency. Following carnitine supplementation, the patient's regression ended, and the boy started gaining developmental milestones. This case report suggests that deficits in carnitine biosynthesis may be responsible for some cases of regression in individuals with ASD, and that testing for the respective biochemical pathway should be considered. Furthermore, this case suggests that carnitine supplementation may be useful in treating (and potentially preventing) regressive episodes in patients with carnitine deficiency. Further work to better define the role of disorders of carnitine biosynthesis in autism spectrum disorder is warranted.

© 2015 Wiley Periodicals, Inc.

dgdavis64
Posts: 5241
Joined: Sun Mar 20, 2005 11:51 pm

Re: Carnitine reverses regressive Autism: a case study

Postby dgdavis64 » Mon May 18, 2015 10:39 pm

Thanks for sharing this carnitine has helped my son a lot.

Beware of the pharma trollbot shills posting from anonymous proxy servers


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