Dietary glycemic index modulates ASD behaviors (mouse model)

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kulkulkan
Posts: 2075
Joined: Tue Mar 13, 2012 1:37 pm

Dietary glycemic index modulates ASD behaviors (mouse model)

Postby kulkulkan » Wed Jun 10, 2015 5:27 pm

Article here
http://www.sciencedaily.com/releases/20 ... 141736.htm
Low glycemic index diet reduces symptoms of autism in mice

Summary:
The number of people diagnosed with autism -- a spectrum of disorders characterized by social avoidance, repetitive behaviors and difficulty communicating -- has risen dramatically over the past two decades for reasons that are unclear. A diet recommended for diabetics ameliorated signs of autism in mice, researchers have found. Although preliminary and not yet tested in humans, the findings might offer clues to understanding one potential cause of autism.

Bread, cereal and other sugary processed foods cause rapid spikes and subsequent crashes in blood sugar. In contrast, diets made up of vegetables, fruits and whole grains are healthier, in part because they take longer to digest and keep us more even-keeled.

New research in a mouse model of autism showed that such low glycemic index diets, similar to the plans that people with diabetes follow to keep their blood sugar in check, reduced symptoms of the disorder in mice. Although preliminary and not yet tested in humans, the findings, published June 9 in the journal Molecular Psychiatry, might offer clues to understanding one potential cause of autism.

The number of people diagnosed with autism -- a spectrum of disorders characterized by social avoidance, repetitive behaviors and difficulty communicating -- has risen dramatically over the past two decades for reasons that are unclear...


Study abstract here:
http://www.ncbi.nlm.nih.gov/pubmed/26055422

Mol Psychiatry. 2015 Jun 9. doi: 10.1038/mp.2015.64. [Epub ahead of print]
Dietary glycemic index modulates the behavioral and biochemical abnormalities associated with autism spectrum disorder.
Currais A1, Farrokhi C1, Dargusch R1, Goujon-Svrzic M1, Maher P1.
Author information
Abstract
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder of unknown etiology, but very likely resulting from both genetic and environmental factors. There is good evidence for immune system dysregulation in individuals with ASD. However, the contribution of insults such as dietary factors that can also activate the immune system have not been explored in the context of ASD. In this paper, we show that the dietary glycemic index has a significant impact on the ASD phenotype. By using BTBR mice, an inbred strain that displays behavioral traits that reflect the diagnostic symptoms of human ASD, we found that the diet modulates plasma metabolites, neuroinflammation and brain markers of neurogenesis in a manner that is highly reflective of ASD in humans. Overall, the manuscript supports the idea that ASD results from gene-environment interactions and that in the presence of a genetic predisposition to ASD, diet can make a large difference in the expression of the condition.

Molecular Psychiatry advance online publication, 9 June 2015; doi:10.1038/mp.2015.64.

lioralourie
Posts: 22
Joined: Sat Jan 18, 2014 12:35 pm

Re: Dietary glycemic index modulates ASD behaviors (mouse model)

Postby lioralourie » Wed Nov 18, 2015 2:04 am

thank you for posting this!


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